Rveiling® PLLA-PEG Injectable Facial Filler
Product Overview
Rveiling® PLLA-PEG Injectable Facial Filler is a milky white, sterile, biodegradable viscous gel implant. Utilizing a pre-filled syringe system, it combines instant filling with long-lasting effects to restore skin tissue volume through injection, achieving facial rejuvenation and aesthetic contouring.
Product Specifications
1 mL/vial, 2 mL/vial, 3 mL/vial
Active Ingredients
Sodium Hyaluronate, PLLA-PEG Microspheres, Lidocaine Hydrochloride, Sodium Chloride, Phosphate Buffered System in Water for Injection.
Structural Composition
Rveiling® PLLA-PEG Facial Filler for Injection is a composite gel system. Its primary components include: PLLA-PEG microspheres (active ingredient, 20.7% formulation concentration) responsible for long-term collagen regeneration stimulation. Cross-linked sodium hyaluronate gel (suspension carrier) providing immediate filling support. Sodium hyaluronate is labeled at 16mg/mL, produced via microbial fermentation and crosslinked with BDDE. The gel carrier additionally contains 0.3% lidocaine hydrochloride to effectively reduce injection discomfort and enhance treatment comfort. All components are sealed within a single-use, pre-filled syringe.
Mechanism of Action
Upon implantation, cross-linked sodium hyaluronate gel immediately provides physical filling to the deep dermis, deep subcutaneous tissue, and superficial periosteum, rapidly improving skin volume and contour.
Long-lasting Maintenance
The PLLA-PEG microspheres within the product act as a bio-scaffold, continuously stimulating endogenous collagen regeneration. This prolongs and optimizes the filling effect, delivering natural, enduring tissue support and skin texture improvement.
Mechanism of Action
Rveiling® Injectable PLLA-PEG Composite Facial Filler achieves sustained collagen regeneration through a “guided regeneration” mechanism. Its action begins with a temporary scaffold formed by degradable PLLA-PEG microspheres and gel. Within weeks of implantation, the material initiates orderly degradation. This process is recognized by the body as a mild regenerative signal rather than an inflammatory signal, precisely recruiting reparative macrophages and fibroblasts. Within the locally formed regenerative microenvironment, fibroblasts are activated and synthesize large amounts of Type I and Type III collagen. Newly synthesized collagen deposits along the original scaffold's spatial structure, while the PLLA material fully degrades over subsequent months. This achieves a natural transition from “physical filling” to “biological regeneration,” enabling long-term, natural volume maintenance and rejuvenation effects through newly formed autologous collagen tissue. PLLA-PEG microspheres degrade progressively through ester bond hydrolysis into lactic acid, ultimately metabolized into carbon dioxide and water, and excreted through natural physiological processes.
Indications
This product is indicated as a dermal filler for injection into the deep dermis, deep subcutaneous tissue, and superficial periosteum to correct facial depressions and contour laxity caused by tissue volume loss.
Sterilization Method
The gel in the pre-filled syringe undergoes high-temperature steam sterilization; the accompanying injection needle is sterilized with ethylene oxide.
Usage Guidelines: This product is for single-use only.
Shelf Life: 24 months.
Precautions: Strict adherence to sterile surgical procedures is mandatory during use. Refer to the enclosed instructions for detailed usage.
Rveiling® PLLA-PEG filler microspheres continuously stimulate fibroblasts to induce the secretion and synthesis of collagen in the human body. Consequently, they are widely used in medical aesthetic fillers and tissue regeneration and repair therapies.
Rveiling® PLLA-PEG Microspheres Continuously Induce Human Fibroblasts to Secret and Synthesize Collagen
Rveiling® PLLA-PEG Microspheres Appearance: Smooth spherical PLLA-PEG microsphere particles, non-toxic, extremely safe, non-irritating, uniform particle size, and comparative biological response effects upon implantation into soft tissue.
Mechanism of action
Degradation Principle
Rveiling® PLLA-PEG microspheres undergo gradual degradation within tissue, stimulating the progressive regeneration of endogenous collagen. As new collagen replaces the original space occupied by the microspheres, it achieves natural filling and structural support effects.
Poly(L-lactic acid) Product Status
Rveiling® PLLA-PEG Facial Filler delivers deep structural support or natural, three-dimensional contouring effects depending on the injection layer.
Key attributes
Specification | 1 mL/vial, 2 mL/vial, 3 mL/vial |
|---|---|
Storage condition | 2-10℃, prohibit freezing, avoid sunlight. |
Transport conditions | Transported at normal temperature, the transport cycle should not exceed1 month. |
Usage Restriction | Do not re-use |
Sterilization Method | High-temperature steam sterilization |
Usage Warning | Do not use if packaging is damaged |
Sterilization Restriction | Do not resterilize |
Cross-linked Sodium Hyaluronate | 16 mg/mL |
Poly(L-lactic acid)-poly(ethylene glycol) microspheres | 20.7 % |
Lidocaine Hydrochloride | 3 mg/mL |
Injection sites
FAQs
Rveiling® PLLA-PEG Injectable Facial Filler
Rveiling® PLLA-PEG Injectable Facial Filler utilizes PLLA-PEG material with excellent biocompatibility to produce microspheres of uniform particle size. PLLA-PEG is an amphiphilic block copolymer primarily applied in biodegradable medical fields. Its hydrophilic outer layer enhances cell adhesion and tissue compatibility. The hydrophobic PLLA segments aggregate to form the core, while the hydrophilic PEG segments extend outward to create the shell. The microspheres are suspended within a gel particle carrier. Following injection and implantation, the gel particles gradually degrade, while the microspheres provide long-term structural support and continuously induce human fibroblasts to secrete and synthesize collagen. Over time, PLLA-PEG undergoes gradual biodegradation.
2. Can outer packaging be customized for OEM or private label production?
Yes. As a professional B2B manufacturer and supplier, we offer OEM and ODM customization services, including logo and packaging design. We support clinics, distributors, and medical aesthetic brands with flexible collaboration models.
3. What are the primary applications of Rveiling® injectable PLLA-PEG facial filler?
Rveiling® PLLA-PEG injectable implant filler is an off-white, viscous, sterile, latex-free, pyrogen-free, semi-solid gel, biodegradable dermal implant filler with immediate results. This implant filler is indicated for correcting facial wrinkles and deep dermal depressions, cheek augmentation, marionette lines, jawline contouring, and restoring/correcting facial fat loss (atrophy) in AIDS patients. Injected into the soft tissue above the periosteum, it provides non-permanent yet long-lasting enhancement.
4. How long do the effects of Rveiling® PLLA-PEG facial filler last?
Typically, results persist for 12 to 24 months, depending on the injection area, the clinician's technique, and the patient's metabolism. The sodium hyaluronate gel carrier delivers immediate filling effects. The gel particles degrade before the microspheres, while the PLLA-PEG microspheres continue to stimulate human fibroblasts to secrete and synthesize collagen, providing long-lasting volume and firmness over time.
5. What certifications and quality standards do you offer for B2B partners?
Our manufacturing strictly adheres to ISO 13485, GMP, and CE certification—globally recognized standards for medical device production quality and safety. Each production batch undergoes rigorous full-performance biological testing, covering biocompatibility, sterility, and all product performance metrics. This stringent process ensures 100% batch compliance, delivering consistent reliability you can trust.
